Liver Cancer HCC tripled in the United States from 1975 through 2005

Journal of Clinical Oncology, Vol 27, No 9 (March 20), 2009: pp. 1485-1491


"The principal findings in this report were that incidence rates of HCC tripled in the United States from 1975 through 2005, with marked recent increases among middle-aged black, Hispanic, and white males"

"Overall age-adjusted incidence rates of HCC tripled between 1975 and 2005, rising from 1.6 per 100,000 to 4.9 per 100,000.....Between 1992 and 2005, overall incidence rates of HCC increased, with an annual percent change of 4.3% (P ≤ .05).....American Indians/Alaska Natives experienced the greatest significant increase (APC = 5.0%), followed by blacks (APC = 4.9%), whites (APC = 4.6%), and Hispanics (APC = 4.0%), look at Table 1 below and you'll much higher incidence rates among Blacks & Hispanics compared to whites, the affects are disproportionate in terms of having HCC and deaths due to HCC (from Jules: this is likely to worse access to care, poor treatment decision making, and undiagnosed HCV/HBV and HCC........(from Jules: there is little or no HCV screening and screening for HCC. There is no Federal support for national screening and surveillance of HCV)......Coordination of existing HCC prevention efforts is needed. Gaps in HCC screening in the United States include limited HCV testing of current and former injected drug users,33 pre-1990 transfusion recipients,34 and incomplete HBV testing of foreign-born Asians/Pacific Islanders.35 In addition, cultural and economic barriers to HCC screening of chronic viral carriers existMuch of the increase in incidence between 2000 and 2005 occurred among men age 50 to 59 years. Not all racial/ethnic groups were equally affected, with black, Hispanic, and white men experiencing the greatest increases.....The changing racial pattern of HCC in this age group may be partially attributable to an epidemic of HCV infection that occurred approximately four decades earlier, in the 1960s, when they were young adults.10 Several findings in this report suggest, however, that risk of HCC is likely to be driven by additional factors.....HCC incidence rates are reported to be higher among Hispanics born in the United States than among foreign-born Hispanics.23 This suggests that factors associated with life in the United States, perhaps including HCV infection,10 alcohol abuse,24 or obesity,25 may be adversely affecting Hispanic populations. here is a need for studies to estimate the current proportion of HCCs that are attributed to HCV and to HBV including differences across demographic groups.9,39..... Associations with suspected cofactors for HCC should also be examined, including alcoholism24 and steatohepatitis,25 obesity,42 diabetes mellitus,43 and iron storage diseases.44.....This report may underestimate recent increases in HCC incidence rates because of delays in reporting16 and an estimated rate of under-reporting of 2.5% because of absence of data on Veterans' Affairs hospital patients,5 a population which may be at elevated risk for HCC compared with the general population"

Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005

Sean F. Altekruse, Katherine A. McGlynn, Marsha E. Reichman

From the Division of Cancer Control and Population Sciences, and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Corresponding author: Sean F. Altekruse, DVM, MPH, PhD, Cancer Statistics Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, 6116 Executive Blvd Suite 504, Bethesda, MD 20892-8316; e-mail: altekrusesf@mail.nih.gov.

ABSTRACT

Purpose - Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Incidence rates are increasing in the United States. Monitoring incidence, survival, and mortality rates within at-risk populations can facilitate control efforts.

Methods - Age-adjusted incidence trends for HCC were examined in the Surveillance, Epidemiology, and End Results (SEER) registries from 1975 to 2005. Age-specific rates were examined for birth cohorts born between 1900 and 1959. Age-adjusted incidence and cause-specific survival rates from 1992 to 2005 were examined in the SEER 13 registries by race/ethnicity, stage, and treatment. United States liver cancer mortality rates were also examined.

Results - Age-adjusted HCC incidence rates tripled between 1975 and 2005. Incidence rates increased in each 10-year birth cohort from 1900 through the 1950s. Asians/Pacific Islanders had higher incidence and mortality rates than other racial/ethnic groups, but experienced a significant decrease in mortality rates over time. From 2000 to 2005, marked increases in incidence rates occurred among Hispanic, black, and white middle-aged men. Between 1992 and 2004, 2- to 4-year HCC survival rates doubled, as more patients were diagnosed with localized and regional HCC and prognosis improved, particularly for patients with reported treatment. Recent 1-year survival rates remained, however, less than 50%.

Conclusion - HCC incidence and mortality rates continue to increase, particularly among middle-aged black, Hispanic, and white men. Screening of at-risk groups and treatment of localized-stage tumors may contribute to increasing HCC survival rates in the United States. More progress is needed.

INTRODUCTION

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide.1 This malignancy occurs more often among men than women, with the highest incidence rates reported in East Asia.2 The incidence rates of HCC in the United States have historically been lower than in many countries. However, in recent decades, HCC age-adjusted incidence rates have doubled3 and primary liver cancer mortality rates have increased faster than mortality rates for any other leading cause of cancer.4,5 Approximately 90% of primary liver cancers in the United States are HCCs, while most of the remaining 10% are intrahepatic cholangiocarcinomas.6 The pathway leading to HCC generally begins with an acute hepatic insult which progresses over decades. Fibrosis and cirrhosis are typically precursors of HCC.7 Among patients with localized stage HCC, treatment options may include resection or transplantation. Chemoembolization, a combination of chemotherapy and occlusion of the tumor blood supply, is reported to improve survival in well-selected patients with unresectable HCC.8 Many patients who are diagnosed with HCC, however, have advanced disease and are only candidates for palliative care, contributing to a relatively low reported 5-year survival rate of approximately 10%.6

Most HCC is thought to be associated with either chronic hepatitis C virus (HCV) or hepatitis B virus (HBV) infection.9 In the United States, more than 3 million people are chronically infected with HCV.10 Many of these individuals were exposed as young adults beginning in the 1960s.10,11 HCV risk factors include contaminated blood product transfusion and injected drug use.10,11

Chronic infection with HBV, a major global risk factor for HCC, is less common overall in the United States than HCV infection is. Among some United States' ethnic groups, however, HBV is a more common risk factor than HCV. For example, a report from Los Angeles found that 74% of HCC among Asians was linked to HBV, while 90% of HCC in whites was linked to HCV.9

The etiology of HCC is likely to involve interactions between multiple risk factors. In a study which utilized the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked databases,12 the most commonly reported risk-factor was nonspecific cirrhosis (21%), followed by alcohol-induced liver disease (16%), HCV infection (10%), and HBV infection (5%). Obesity and type II diabetes6 are also suspected to increase risk.

To monitor changes in the burden of HCC in the United States, this report provides analyses of incidence and survival of HCC and mortality of liver cancer. To define at-risk populations, data were examined by sex, race/ethnicity, and age.

RESULTS

Age-Adjusted HCC Incidence Data

Overall age-adjusted incidence rates of HCC tripled between 1975 and 2005, rising from 1.6 per 100,000 to 4.9 per 100,000 (Fig 1). Incidence rates were approximately three times higher among men than among women throughout this time period. The best fitting model for overall HCC incidence trends had two segments. The first segment, from 1975 to 1980, showed no change in HCC incidence. The second segment, fitting HCC incidence trends from 1980 to 2005, estimated an annual percent change of 4.5% (P ≤ .05). When rates among males and females were modeled separately, the best-fitting joinpoint models had one segment. The annual percent changes in HCC incidence from 1975 to 2005 were statistically significant in both models (P ≤ .05).

Birth Cohort Analyses

Examining age-specific incidence by birth cohort revealed that rates increased in each successive birth cohort born between 1900 and 1959 (Fig 2). Incidence rates for the most recent surveillance years (marked with asterisks) were not adjusted for delayed reporting or final cases in the last birth years of each cohort.

Age-Adjusted Rates by Race and Ethnicity

Between 1992 and 2005, overall incidence rates of HCC increased, with an annual percent change of 4.3% (P ≤ .05; Table 1). Asians/Pacific Islanders had the highest age-adjusted HCC incidence rates throughout the period, followed by Hispanics, blacks, American Indians/Alaska Natives and whites (Table 1). Although Asians/Pacific Islanders had the highest incidence, they experienced a smaller annual percent change in HCC incidence rates (annual percent change [APC] = 1.0%) than other racial/ethnic groups. American Indians/Alaska Natives experienced the greatest significant increase (APC = 5.0%), followed by blacks (APC = 4.9%), whites (APC = 4.6%), and Hispanics (APC = 4.0%). For each trend, the best-fitting joinpoint model had one segment.

Table 1. Age-Adjusted HCC Incidence Rates, Liver Cancer Death Rates, and 1-Year Cause-Specific Survival Rates for HCC, From 1992 to 2005 by Time Period and Race/Ethnicity, With APC

United States Versus Foreign Place of Birth

Data on place of birth were available for 81% of persons with HCC diagnosed in the SEER 13 registries between 2000 and 2005, including more than 80% of patients in all racial groups and 77% of Hispanic patients (data not shown). Among patients with data, 31% were born outside the United States; however, 80% of Asians/Pacific Islanders with data were born outside the United States, more than any other racial or ethnic group. Among Hispanics with HCC, 40% were born outside the United States. Compared with Asian/Pacific Islander and Hispanic HCC cases, foreign birth occurred less frequently among white (17%), black (6%), and American Indian/Alaska Native HCC patients (3%) with data.

Recent Incidence Trends

An examination of age-specific HCC incidence rates in SEER 13 registries in 2000 to 2002 and 2003 to 2005 revealed marked increases in incidence rates among men 50 to 59 years of age and 75 to 84 years of age (Fig 3) with slight increases in incidence rates among women in these age groups.

Within the 50- to 59-year age group, the annual percent change in HCC incidence rates significantly increased from 2000 to 2005 for Hispanic men, black men, and white men, and for black and white women (P ≤ .05), with HCC incidence rates among blacks exceeding those of Asians/Pacific Islanders during 2003 to 2005 (Table 2). Among persons 75 to 84 years of age, increases in HCC incidence were seen among all men and white women (P ≤ .05). No other significant annual percent changes were seen from 2000 to 2005 by age, sex, or race/ethnicity (data not shown).

Age-Adjusted Liver Cancer Mortality Data

Between 1992 and 2005, patterns in liver cancer mortality were similar to patterns in HCC incidence. Overall age-adjusted mortality rates increased, with an annual percent change of 1.6% (P ≤ .05). Mortality rates were highest for Asians/Pacific Islanders, followed by Hispanics, blacks, American Indians/Alaska Natives, and finally whites (Table 1). Rates increased significantly among Hispanics and whites (APC = 1.7%) as well as blacks (APC = 1.3%). Mortality rates among Asians/Pacific Islanders, however, significantly declined (APC = –0.9%), with stable mortality rates among American Indian/Alaska Native populations.

Survival Rates

One-year cause-specific survival rates increased over time for all racial/ethnic groups except American Indians/Alaska Natives (Table 1). During the recent years, 2003 to 2004, the overall 1-year survival rate was 47% (range, 40% for blacks to 49% for Asian/Pacific Islanders).

Overall, survival rates increased for short, intermediate, and longer-term follow-up intervals over the time period of study, with a doubling of 2- to 4-year cause-specific survival rates (Table 3). These increases in survival rates occurred as more patients were diagnosed with localized stage HCC (28% in 1992 to 1993, 44% in 2003 to 2004) and 1-year survival rates for patients with localized HCC increased from 41% to 67%. Among patients with localized HCC that reported therapy, 1-year survival rates increased from 65% in 1992 to 1993 to 83% in 2003 to 2004. One-year survival rates for patients with localized HCC who received surgery increased from 81% to 91% between 1992 to 1993 and 2003 to 2004 (data not shown). Survival rates also increased among patients with regional HCC who reported therapy. Although changes in survival rates for cases with distant HCC were less pronounced, patients reporting treatment had higher survival rates.

DISCUSSION

The principal findings in this report were that incidence rates of HCC tripled in the United States from 1975 through 2005, with marked recent increases among middle-aged black, Hispanic, and white males; there was a birth-cohort effect on risk; and overall 1-year cause-specific survival rates for new HCC patients nearly doubled from 1992 to 2004 as more patients were diagnosed with low-stage HCC and their prognosis improved. Increases in cause-specific survival rates were experienced by all racial and ethnic groups, except for American Indians/Alaska Natives. However, despite increasing HCC survival rates, improvement is needed, with the 1-year cause-specific survival rate remaining lower than 50%.

Much of the increase in incidence between 2000 and 2005 occurred among men age 50 to 59 years. Not all racial/ethnic groups were equally affected, with black, Hispanic, and white men experiencing the greatest increases. Between 2003 and 2005, for both sexes, blacks in this age group had higher incidence rates than Asian/Pacific Islanders. The changing racial pattern of HCC in this age group may be partially attributable to an epidemic of HCV infection that occurred approximately four decades earlier, in the 1960s, when they were young adults.10 Several findings in this report suggest, however, that risk of HCC is likely to be driven by additional factors. There has been a steady increase in age-adjusted HCC incidence rates among men and women since 1975. Age-specific rates have increased in each successive birth cohort between 1900 and 1959. Etiologic studies of recent HCC patients are recommended to elucidate factors contributing to the ongoing increase in HCC incidence.

In contrast with other racial groups, most Asians/Pacific Islanders with HCC were born outside the United States. This predominance of foreign births is consistent with HBV infection being a major risk factor among most groups of Asians/Pacific Islanders9,20 as chronic HBV infection is notably more common in eastern Asian countries than in the United States, with higher HCC incidence rates among Southeast Asians compared with Filipinos, Japanese, and Asian Indians/Pakistanis.19 An exception is Japan, where more HCC patients are linked to HCV infection than HBV infection.21 The modest increase in HCC incidence rates and decrease in liver cancer mortality rates from 1992 to 2005 suggests that Asians/Pacific Islander populations born in the United States have, thus far, not been as affected by the factors that are driving the HCC increases in other populations. Worldwide, the incidence of HCC among Asians/Pacific Islanders is likely to decline as HBV vaccination becomes more widespread in Asian countries.22

In this study, HCC incidence rates among Hispanics were lower than among Asians/Pacific Islanders, but higher than among whites. Approximately one half of Hispanic HCC patients were born in the United States. In contrast to Asians/Pacific Islanders, HCC incidence rates are reported to be higher among Hispanics born in the United States than among foreign-born Hispanics.23 This suggests that factors associated with life in the United States, perhaps including HCV infection,10 alcohol abuse,24 or obesity,25 may be adversely affecting Hispanic populations.

Despite a paucity of new therapies for HCC during the surveillance years in this report, 1-year cause-specific survival rates for HCC nearly doubled between 1992 to 1993 and 2003 to 2004. This supports earlier evidence that survival rates for HCC are increasing.26 Initially, the increase in survival was restricted to short-term follow-up27; however, in this report 4-year survival rates doubled and 5-year survival rates increased by more than 60%. Furthermore, more patients were diagnosed with localized and regional stage HCC and survival rates increased for these patients. With greater awareness of HCC, more patients are being diagnosed with asymptomatic disease via active screening employing serum alpha-fetoprotein testing, abdominal ultrasound, and diagnostic imaging.28 Furthermore, aggressive treatments including transplantation and resection of localized-stage tumors appear to be improving long-term survival.29 The advent of targeted HCC therapies holds promise for further improvement in prognosis among patients with regional and distant-stage HCC.30

Racial variation was seen in 1-year cause-specific survival rates. In 2003 to 2004, survival was greatest among Asians/Pacific Islanders (49%) and lowest among blacks (40%) and American Indians/Alaska Natives (41%). In another study, racial and ethnic variations in survival were partially explained by stage at diagnosis and the therapy received by blacks and Hispanics compared with whites.26 While improvements in survival are needed across all racial and ethnic groups, blacks and American Indians/Alaska Natives may particularly benefit from targeted HCC control efforts.

Coordination of existing HCC prevention efforts is needed. Primary HCC prevention measures include hepatitis B vaccination programs,22 screening of the blood supply for hepatitis viruses,31 and campaigns to discourage intravenous drug abuse. Secondary prevention measures focus on detecting asymptomatic HCC among at-risk individuals28 through periodic screening of high-risk patients by ultrasound, with follow-up tests when suspicious lesions are detected.32 High-risk individuals include cirrhotic patients, adult HBV carriers, and persons infected with HCV. Gaps in HCC screening in the United States include limited HCV testing of current and former injected drug users,33 pre-1990 transfusion recipients,34 and incomplete HBV testing of foreign-born Asians/Pacific Islanders.35 In addition, cultural and economic barriers to HCC screening of chronic viral carriers exist.36,37 Tertiary measures for HCC vary by stage of disease and comorbidity but include surgical resection, transplantation, radiofrequency ablation, and chemoembolization.28 A SEER-Medicare linked study of HCC patients diagnosed in the 1990s indicated that only one third of cases with favorable tumor features received potentially curative therapy.38

A limitation of this study is the absence of information on risk factors. There is a need for studies to estimate the current proportion of HCCs that are attributed to HCV and to HBV including differences across demographic groups.9,39 Studies are needed of the oncogenic potential of viral genotypes.40,41 Associations with suspected cofactors for HCC should also be examined, including alcoholism24 and steatohepatitis,25 obesity,42 diabetes mellitus,43 and iron storage diseases.44

This report may underestimate recent increases in HCC incidence rates because of delays in reporting16 and an estimated rate of under-reporting of 2.5% because of absence of data on Veterans' Affairs hospital patients,5 a population which may be at elevated risk for HCC compared with the general population.45 Despite these limitations, the findings strongly suggest that HCC incidence and mortality continue to increase in the United States. In addition, this report provides reason for optimism that, with more HCC screening of high-risk groups and treatment of low-stage disease, the burden of HCC can be lessened.